Takashi Harimoto

Assistant Professor, Institute for Molecular Science

Date/Place of Birth

November 1, 1997 / Yokohama, Kanagawa, Japan

Education

B.S. in Chemistry, Mar 2020 (Prof. Takanori Suzuki, Hokkaido University)

M.S. in Chemisty, Sep 2021 (Prof. Takanori Suzuki, Hokkaido University)

JSPS Research Fellowships for Young Scientists, Apr 2022 – Mar 2024

Ph.D. in Chemistry, Mar 2024 (Prof. Takanori Suzuki, Hokkaido University)

Academic Career

Apr 2024 – current position 

Publications

17) Structural-Change-Induced Two-Stage Redox Behavior of Pentacenebisquinodimethane with Tricolor Chromism.
Y. Ishigaki, S. Mizuno, T. Harimoto, T. Shimajiri, T. Suzuki
Chem. Asian J. 2024, in press.   [DOI: 10.1002/asia.202400316]

16) Domino-Redox Reaction Induced by An Electrochemically Triggered Conformational Change.
T. Harimoto, T. Tadokoro, S. Sugiyama, T. Suzuki, Y. Ishigaki
Angew. Chem. Int. Ed. 2024, 63, e202316753.   [DOI: 10.1002/anie.202316753]
Highlighted in Chem-Station Spotlight Research No. 597

15) Carbon-based Biradicals: Structural and Magnetic Switching.
Y. Ishigaki, T. Harimoto, T. Shimajiri, T. Suzuki
Chem. Rev. 2023, 123, 13952-13965.   [DOI: 10.1021/acs.chemrev.3c00376]

14) Synthesis and Functional Control of Near-infrared Electrochromic Molecules Based on Redox-active Para-quinodimethane Scaffolds.
T. Harimoto, Y. Ishigaki
J. Synth. Org. Chem. Jpn. 2023, 81, 963-977.   [DOI: 10.5059/yukigoseikyokaishi.81.963]

13) Double Dynamic Structural Change Enabling Tricolor Chromism by the Realization of Apparent Two-Electron Transfer to Skip the Open-Shell State.
T. Harimoto, Y. Sugai, K. Sugawara, T. Suzuki, Y. Ishigaki
Chem. Eur. J. 2023, 29, e202301476.   [DOI: 10.1002/chem.202301476]

12) One-Pot Synthesis of Helical Azaheptalene and Chiroptical Switching of an Isolable Radical Cation.
Y. Nishimura, T. Harimoto, T. Suzuki, Y. Ishigaki
Chem. Eur. J. 2023, 29, e202301759.   [DOI: 10.1002/chem.202301759]
Preprint: ChemRxiv 2023 [DOI: 10.26434/chemrxiv-2023-sc6tf]

11) Enhancement of NIR-Absorbing Ability of Bis(diarylmethylium)-Type Dicationic Dyes Based on an Ortho-Substitution Strategy.
T. Harimoto, T. Suzuki, Y. Ishigaki
Chem. Eur. J. 2023, 29, e202203899.   [DOI: 10.1002/chem.202203899]

10) Single-Molecule Observation of Redox Reactions Enabled by Rigid and Isolated Tripodal Molecules.
Y. Kobayashi, Y. Yokota, R. A. Wong, M. Hong, J. Takeya, S. Osawa, F. Ishiwari, Y. Shoji, T. Harimoto, K. Sugimoto, Y. Ishigaki, T. Suzuki, T. Fukushima, Y. Kim
J. Phys. Chem. C 2023, 127, 746-758.   [DOI: 10.1021/acs.jpcc.2c07362]

9) Geometrical and Electronic Structure of Cation Radical Species of Tetraarylanthraquinodimethane: An Intermediate for Unique Electrochromic Behavior.
Y. Ishigaki, R. Fukagawa, K. Sugawara, T. Harimoto, T. Suzuki
Chem. Asian J. 2022, 17, e202200914.   [DOI: 10.1002/asia.202200914]

8) A Ratiometric Photoacoustic Probe with a Reversible Response to Hydrogen Sulfide and Hydroxyl Radicals for Dynamic Imaging of Liver Inflammation.
L. Wu, W. Zeng, Y. Ishigaki, J. Zhang, H. Bai, T. Harimoto, T. Suzuki, D. Ye
Angew. Chem. Int. Ed. 2022, 61, e202209248.   [DOI: 10.1002/anie.202209248]

7) Redox-Active Hydrocarbons: Isolation and Structural Determination of Cationic States toward Advanced Response Systems.
T. Harimoto, Y. Ishigaki
ChemPlusChem 2022, 87, e202200013.   [DOI: 10.1002/cplu.202200013]

6) An Activatable Afterglow/MRI Bimodal Nanoprobe with Fast Response to H₂S for In Vivo Imaging of Acute Hepatitis.
W. Zeng, L. Wu, Y. Ishigaki, T. Harimoto, Y. Hu, Y. Sun, Y. Wang, T. Suzuki, H.-Y. Chen, D. Ye
Angew. Chem. Int. Ed. 2022, 61, e202111759.   [DOI: 10.1002/anie.202111759]

5) Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy.
L. Wu,^# Y. Ishigaki,^# W. Zeng,^# T. Harimoto, B. Yin, Y. Chen, S. Liao, Y. Liu, Y. Sun, X. Zhang, Y. Liu, Y. Liang, P. Sun, T. Suzuki, G. Song, Q. Fan, D. Ye
Nat. Commun. 2021, 12, 6145.   [DOI: 10.1038/s41467-021-26380-y (open access)]
^#These authors contributed equally.

4) Redox-active tetraaryldibenzoquinodimethanes.
Y. Ishigaki, K. Sugawara, T. Tadokoro, Y. Hayashi, T. Harimoto, T. Suzuki
Chem. Commun. 2021, 57, 7201-7214.   [DOI: 10.1039/D1CC02260A]

3) Hysteretic Three-State Redox Interconversion among Zigzag Bisquinodimethanes with Non-fused Benzene Rings and Twisted Tetra-/Dications with [5]/[3]Acenes Exhibiting Near-Infrared Absorptions.
Y. Ishigaki, T. Harimoto, K. Sugawara, T. Suzuki
J. Am. Chem. Soc. 2021, 143, 3306-3311.   [DOI: 10.1021/jacs.1c00189]
• Highlighted in Chem-Station Spotlight Research No. 308

2) Hexaarylbutadiene: A Versatile Scaffold with Tunable Redox Properties towards Organic Near-Infrared Electrochromic Material.
Y. Ishigaki, T. Harimoto, K. Sugimoto, L. Wu, W. Zeng, D. Ye, T. Suzuki
Chem. Asian J. 2020, 15, 1147-1155.   [DOI: 10.1002/asia.201901816]

1) H₂S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo.
L. Wu,^# Y. Ishigaki,^# Y. Hu, K. Sugimoto, W. Zeng, T. Harimoto, Y. Sun, J. He, T. Suzuki, X. Jiang, H.-Y. Chen, D. Ye
Nat. Commun. 2020, 11, 446.   [DOI: 10.1038/s41467-020-14307-y (open access)]
^#These authors contributed equally.

Awards and Honors

2019 Poster Award, The 30th Symposium of the Society of Physical Organic Chemistry, Japan (JPOC)

2020 Alumini Award 2019, Faculty of Science, Hokkaido University

2021 Best Poster Award, The 33rd Banyu Sapporo Symposium

2021 Poster Award, The 31st Symposium of JPOC

2022 Poster Award, The 32nd Symposium of JPOC

2022 The 13th Otsu Conference Award Fellow

2022 Best Discussion Award, The 2nd Online Symposium on Physical Organic Chemistry for Young Chemists

2024 Oral Presentation Award, The 104th CSJ Annual Meeting (2024)